The PTC has written to the House and Senate judiciary committees stating that the show may violate federal pornography statutes.
Last week Viacom, the conglomerate which owns MTV, had reportedly asked producers to "tone down" the more explicit content.
PTC's campaign against Skins has led to Taco Bell and General Motors pulling their ads from the show.
"Every single advertiser who sponsored the premiere episode of Skins is not only endorsing but glorifying teen drug and alcohol abuse, not to mention a plethora of baseless sexual content," the group said.
Its efforts however, did not stop the show pulling in the largest number of viewers aged 12 to 34 for a show launch in MTV's history. Some 3.3 million Americans tuned in to watch the premiere on Monday night, with at least a million believed to be aged 18 or younger.
MTV defended Skins in a statement.
"We review all of our shows and work with all of our producers on an ongoing basis to ensure our shows comply with laws and community standards," it said.
"We are confident that the episodes of 'Skins' will not only comply with all applicable legal requirements, but also with our responsibilities to our viewers.
"We also have taken numerous steps to alert viewers to the strong subject matter so that they can choose for themselves whether it is appropriate."
Skins has amassed something of a cult following among young people in Britain since it first aired on Channel Four in 2007. A Skins spin-off novel came out last year and a film is in production.
The series has faced criticism for its sex, drug and drink-fuelled depictions of British teenagers.