The event on June 12 and 13 will see top Catholic leaders, including Cardinal Jean-Louis Pierre Tauran, president of the Pontifical Council for Inter-religious Dialogue; and Cardinal Oswald Gracias, Archbishop of Mumbai.
Representing the Hindus religion will be noted personalities that include Shankaracharya of the Kanchi Kamakoti Mutt, Sri Jayendra Saraswati Swamiji and Sri Sri Ravi Shankar.
The interaction comes in the wake of growing sectarian and religious violence on Christians, including the 'conversion' allegations that have been a bone a contention among religious groups.
The anti-Christian pogroms in Orissa and Karnataka has also deeply miffed the Church which vies to iron out the misunderstanding and negative attitudes of Hindu fanatic groups who are apparently on a revenge spree after the murder of Swami Laxmananda Saraswati.
Last August, the violence in the eastern Indian state killed over 60 Christians; wounded 18,000; 181 churches, razed or destroyed; 4,500 Christian homes, burned; and more than 50,000 Christians, displaced.
The organizer of the event, Cardinal Gracias says, the attack on minorities has called for an urgent need for 'understanding' among religious groups.
The first day, says the Cardinal, will be a dialogue between the Catholic and Hindu religious leaders. The second day will be an interaction between representatives of other faith - the Muslim, Sikh, and Buddhist community.
The organizers are expecting at least 1,200 people in the significant event, which is said to be the "first official meeting between the pope's representatives and top Indian Hindu religious leaders."