Speaking before hundreds at Sydney's Town Hall, the mathematician and best-selling author pointed out that the contemporary notion arose from leading intellects coming to a "false conclusion" about God.
"The first thing to get clear is to remove the fog about God," Dr Lennox said. "We're not claiming that God is simply an explanation for what science cannot yet explain."
Lennox stated that equating both 'God' and 'science' as explanations meant that the two were defined in such a way as to inevitably 'compete'.
"If you believe in a 'God of the gaps' then you have to choose between science and God, because that's the way you've defined God."
"God no more competes with science as an explanation than Henry Ford competes with the law of internal combustion as an explanation for the motor car engine," the Christian apologist explained.
"What is being suggested to you by many of these people is precisely that. You're being asked to choose between Henry Ford and internal combustion - you'd never dream of doing it."
Dr Lennox also encouraged younger generations to ask the "bigger questions".
Noting prominent Christian figures of the past such as Thomas Aquinas and Saint Augustine, the academic who has debated well known atheists including Richard Dawkins and Peter Singer, said that the "anti-intellectual element" within Christian churches in recent years was a "tragedy".
"They were the real thinkers of the ancient world...the people that founded our major universities were thinking Christians," he said.
"It's a tragedy that somehow people got frightened of science in a way and started to batten down the hatches."
The event marked the end of Lennox's Cosmic Chemistry: Do Science and God mix? tour across the country, having already spoken in Melbourne, Adelaide, Perth and Brisbane.
For more information or to get involved in asking the 'bigger' questions, visit citybibleforum.org