The action-packed superhero movie already had the highest opening weekend after taking in $103.2 million in the US alone.
Now it's bagged the record for the biggest second weekend sales as well, after amassing $373.2 million in domestic sales and another $628.9 internationally just 19 days after it opened.
The Marvel blockbuster bumped Johnny Depp and Tim Burton's vampire flick, Dark Shadows, into a distant second with domestic sales of $28.8 million.
The Avengers stars Chris Evans as Captain America, Robert Downey Jr as Tony Stark and Scarlett Johansson as the Black Widow.
The previous top seller on a second weekend was Avatar, with $75.6 million.
Christian educational charity Damaris Trust has produced a discussion guide to help people talk through some of the themes that emerge in the film.
The guide can be found here: www.damaris.org/content/culturewatchguides/519